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Intake and Growth Performance of Clinically Ill Cattle Treated with Nuflor® Injectable Solution or Baytril® 100.

Abstract:

In the fall of 2006, a randomized, masked clinical study was conducted at a contract research organization to determine the effect of NUFLOR (florfenicol) or Baytril 100 (enrofloxacin) treatments on feed intake in clinically ill animals. The intake data was measured using the Grow Safe feed intake system. In the 60 days following BRD treatment, animals dosed with NUFLOR (florfenicol) ate on average 21.58 lb/day while cattle treated with Baytril (enrofloxacin) consumed on average 21.38 lb/day. These
intakes were not statistically different (p=0.68). Additionally, there was no statistical difference in feed intake at 7 days post treatment between the two groups (10.67 vs. 11.01; p=0.62). In this controlled clinical study there were no significant feed intake
differences in animals treated for BRD with either Baytril (enrofloxacin) or NUFLOR (florfenicol).

Study Design

Animals:

Steer/Bull
Beef
80 Animals Enrolled in the Study
(40/Treatment)
Average In Weight 596 lbs

Design of Trials:

Timing: Fall 2006
Randomized, Blinded Clinical Trial
Trial Type: Feed Intake trial
Trial Duration: 60 days
Location: Texas Panhandle

Inclusion Criteria:

Acute Respiratory Disease
Clinical Scoring System (score 0 - 3)
Respiratory Score > 1 and Rectal Temperature ≥ 104.00F

Depression Score > 1 and Rectal Temperature ≥ 104.00F

Results

Intake Following BRD Treatment:
After treatment with NUFLOR (florfenicol) or Baytril 100 enrofloxacin), most time periods showed no statistical differences in feed intake. One time period, 40 to 60 d following treatment, approached statistical significance (p = 0.06) with the cattle treated with NUFLOR (florfenicol) exhibiting greater average feed intake (Table 1, Chart 1). Body weights were similar among NUFLOR (florfenicol) and Baytril (enrofloxacin) treated cattle at enrollment, and 20, 40 and 60 d posttreatment.

Table 1 - Results
	NUFLOR 40 mg/kg		Baytril 12.5 mg/kg		P-value
Variable	Mean	S.E	Mean	S.E
Intake 0 to 7 d post trt¹	10.67	0.47	11.01	0.47	0.62
Intake 0 to 20 d post trt¹	13.75	0.41	14.45	0.41	0.24
Intake 20 to 40 d post trt¹	24.10	0.60	24.28	0.60	0.83
Intake 40 to 60 d post trt¹	26.98	0.53	25.52	0.53	0.06
Intake 0 to 60 d post trt¹	21.58	0.31	21.39	0.2	0.69
BW at enrolment¹	568	6.6	571	6.6	0.73
20 d BW	609	8.7	612	8.8	0.77
40 d BW	695	11.8	708	11.8	0.44
60 d BW	744	14.4	772	4.6	0.18

¹These represent intakes on days that are specific to animals and depend on when they were enrolled.

Chart 1. Feed Intake Data

comparison Nuflor Baytril

Intake and Growth Performance of Clinically Ill Cattle Treated with Nuflor® Injectable Solution or Baytril® 100.

Abstract:

Study Design

Results

Table 1 - Results

Chart 1. Feed Intake Data