 New Antibiotic Sensitivity Testing Results NuflorŪ (florfenicol) an Excellent Choice for First-Line BRD Therapy Antibiotic Sensitivity is a critical factor in
choosing the correct antibiotic for the treatment of
Bovine Respiratory Disease (BRD). A 2007 annual
report from the Iowa State Veterinary Diagnostic
Laboratory describes the antimicrobial sensitivity
patterns of the major bacterial pathogens causing
BRD (Table 1 and Figure 1). Bacteria are tested
under controlled laboratory settings by trained
microbiologists to determine the antibiotic sensitivity of disease-causing organisms. This
information provides the veterinary practitioner
valuable insight to optimize BRD therapy. As you note, the results of antibiotic sensitivity
testing are reported by the specific bacterial
species and the generic antibiotic name (see Table 1
and Table 2). Table 1: 2007 Antimicrobial Sensitivity Testing for Major Pathogens of BRD Percentage (%) of BRD Isolates Susceptible to Various Antibiotics Following In Vitro MIC Testing| Antibiotic | Mannheimia
haemolytica
(n=130) | Pastuerella
multocida
(n=119) | Histophilus
somni
(n=55) | | Ceftiofur | 100% | 100% | 100% | | Danofloxacin | 76% | 88% | 84% | | Enrofloxacin | 80% | 93% | 95% | | Florfenicol | 85% | 90% | 95% | | Oxytetracycline | 56% | 70% | 55% | | Spectinomycin | 72% | 76% | 67% | | Tilmicosin | 61% | 64% | 93% | | Tulathromycin | 80% | 87% | 86% | Table 2: Antibiotic Generic Trade Names Listed by Antibiotic Class | Antibiotic class | Generic Names | Antibiotic Trade Names | | Beta Lactam | Penicillin | Duo-Pen,® Dura-Pen | | Ceftiofur | Naxcel,® Excenel,® Excede® | | Fluoroquinolones | Danofloxacin | A180® | | Enrofloxacin | Baytril® | | Phenicol | Florfenicol | Nuflor | | Tetracyclines | Chlortetracycline | Aureomycin,® CTC | | Oxytetracycline | Biomycin,® LA200,® Tetradure® | | Macrolides | Tilmicosin | Micotil® | | Tulathromycin | Draxxin® |
Figure 1. Antibiotic Sensitivity Testing Results for Bacteria Causing BRD These results indicate an excellent sensitivity
profile for florfenicol against the primary pathogens
of BRD.1There are other factors that are important
in choosing an antibiotic, and many of these
factors allow for the injected antibiotic to reach
the diseased tissues quickly and in high enough
concentrations to treat disease.
Florfenicol is a very lipophilic antibiotic. This means
that after injection with Nuflor,® florfenicol readily
enters tissues, which results in wide distribution
of antibiotic. When we take this new sensitivityinformation with the tissue distribution and speed of
action, we can be confident that Nuflor® (florfenicol)
is an excellent first choice for treating BRD. Antibiotic Selection Factors: - Spectrum of Activity
- Speed of Action
- Tissue Distribution
- Antibiotic Sensitivity
- Withdrawal Time
1 The correlation between in vitro suceptibility data and clinical response has not been determined for all antibiotics.  
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