Nuflor®(florfenicol) an Excellent Choice for First-Line BRD Therapy
Antibiotic Sensitivity is a critical factor in
choosing the correct antibiotic for the treatment of
Bovine Respiratory Disease (BRD). A 2007 annual
report from the Iowa State Veterinary Diagnostic
Laboratory describes the antimicrobial sensitivity patterns of the major bacterial pathogens causing BRD (Table 1 and Figure 1). Bacteria are tested under controlled laboratory settings by trained
microbiologists to determine the antibiotic sensitivity of disease-causing organisms. This information provides the veterinary practitioner valuable insight to optimize BRD therapy.
As you note, the results of antibiotic sensitivity testing are reported by the specific bacterial species and the generic antibiotic name (see Table 1 and Table 2).
Table 1: 2007 Antimicrobial Sensitivity Testing for Major Pathogens of BRD
Table 2: Antibiotic Generic Trade Names Listed by Antibiotic Class
|Antibiotic class||Generic Names||Antibiotic Trade Names|
|Beta Lactam||Penicillin||Duo-Pen,® Dura-Pen|
|Ceftiofur||Naxcel,® Excenel,® Excede®|
|Oxytetracycline||Biomycin,® LA200,® Tetradure®|
Figure 1. Antibiotic Sensitivity Testing Results for Bacteria Causing BRD
These results indicate an excellent sensitivity
profile for florfenicol against the primary pathogens
of BRD.1There are other factors that are important
in choosing an antibiotic, and many of these
factors allow for the injected antibiotic to reach the diseased tissues quickly and in high enough concentrations to treat disease.
Florfenicol is a very lipophilic antibiotic. This means that after injection with Nuflor,® florfenicol readily enters tissues, which results in wide distribution of antibiotic. When we take this new sensitivityinformation with the tissue distribution and speed of
action, we can be confident that Nuflor® (florfenicol) is an excellent first choice for treating BRD.
Antibiotic Selection Factors:
1 The correlation between in vitro suceptibility data and clinical response has not been determined for all antibiotics.